Our Research

Organ Transplantation & Xenotransplantation - Improving Transplant Outcomes: From Allografts to Xenografts.

Our lab is deeply committed to advancing the field of organ transplantation, focusing on both conventional allograft (human-to-human) procedures and the groundbreaking frontier of xenotransplantation (pig-to-human). A significant area of our research centers on kidney and heart xenotransplantation, where we meticulously analyze the complex immune responses and cellular dynamics in pig-to-human models. We employ longitudinal multi-omic profiling to uncover the molecular mechanisms of rejection and acceptance, aiming to develop novel strategies that enhance transplant success and to understand immunologic barriers in cross-species transplantation. Our work also extends to improving long-term human kidney allograft survival by exploring innovative approaches to HLA compatibility and the role of non-HLA genes.

Precision Genetics & Multi-Omics - Unlocking Biological Insights Through Genomic and Multi-Omic Profiling

At the core of our research is the application of advanced genomic and multi-omic technologies to unravel the genetic and molecular underpinnings of disease and transplant outcomes. We use comprehensive approaches such as whole genome sequencing for family-based rare variant association analysis, as exemplified by our studies in rare and common diseases impacting end-stage disease precipitating transplantation, to identify novel genetic determinants. Furthermore, our lab specializes in integrative multi-omics profiling, combining data from genomics, transcriptomics, proteomics, and metabolomics to provide a holistic view of biological systems. This allows us to gain unprecedented insights into the intricate molecular responses in various biological contexts, including the detailed analysis of host-graft interactions in transplantation.

Immunogenetics & Transplant Compatibility - Optimizing Compatibility: Immunogenetics, Equity, and Rejection Pathology

A critical aspect of successful transplantation lies in understanding and optimizing immunologic compatibility. Our lab investigates immunogenetics, particularly focusing on Human Leukocyte Antigen (HLA) matching and the implications of eplet mismatch for deceased-donor kidney allocation. We conduct crucial research into balancing equity and maximizing compatibility, addressing racial disparities in transplant access. Beyond compatibility, we delve into the immune response post-transplantation, conducting multimodal phenotyping studies to characterize early immune responses and rejection pathology in detail, including antibody-mediated injury. These efforts are aimed at developing targeted therapeutic interventions to overcome rejection and ensure the long-term viability of transplanted organs.